Droplet microfluidics for kinetic studies of viral fusion
نویسندگان
چکیده
منابع مشابه
Droplet microfluidics for kinetic studies of viral fusion.
Viral infections remain a major threat to public health. The speed with which viruses are evolving drug-resistant mutations necessitates the further development of antiviral therapies with a large emphasis on drug discovery. To facilitate these efforts, there is a need for robust, high-throughput assays that allow the screening of large libraries of compounds, while enabling access to detailed ...
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Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of "digital fluidic" operations that can be rendered programmable and reconfigurable. This platform has dimensional scaling benefits that have enabled controlled and rapid mixing of fluids in the droplet reactors, resulting in decreased reaction time...
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Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to concomitant reductions in cost. Manipulation and measurement at kilohertz speeds enable up to 10(8) samples to be screened in one day. Compartmentalization in droplets increases assay sensitivity by increasing the ...
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Droplet microfluidics (DMF) is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can generate external stimuli, to either actively or passively control the shape and positioning of f...
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Here we demonstrate a novel concept of liquid-in-gas droplet microfluidics by using gas flow as the continuous phase for the production of liquid droplets. Within a specially configured co-flow microfluidic tubing device, a flow of liquid phase has been continuously dispersed into another outer stream of gas phase, producing discrete and monodisperse microdroplets. This process is robust and we...
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ژورنال
عنوان ژورنال: Biomicrofluidics
سال: 2016
ISSN: 1932-1058
DOI: 10.1063/1.4943126